What is Cellular Therapy?
Cellular therapies can deposit cells, growth factors, and matrix components locally at the site of damage or arthritis; some therapies may be delivered systemically to serve distant organs and nerves. At BOUNDLESS, we can access cells from your own bone marrow and cushioning/protective microfat, or activated blood components–all with the goal of controlling inﬂammation, relieving pain, and healing your tissues naturally.
Our patients value their experience...
You’ve been going out of your way to help me–and I want to thank you.
Thank you just isn’t enough. You have no idea of the difference you have made in my life. I’ve gone from totally discouraged and completely worn down from chronic pain to optimistic, excited, and happy. YOU have made that difference in me.
I love your spirit and am grateful that [my partner] has you as his doctor. You are a caring guide on his path of learning to manage his pain.
Why do you think I am back? You are HONEST and I like you–and surgery is the last option.
There are not adequate words to thank you for what I feel in my heart, my mind, and my body. I have my life back! Each day is so very special. How do you find the words to begin to thank you for that? I could not have been more pleased with your personal sensitivity.
Cellular Therapy FAQs
Are there any ethical issues with cellular therapy?
What conditions may benefit from cellular therapy?
Are there any side effects to cellular therapy?
What are the potential benefits of cellular therapy?
How do you get the cells?
How do I know if the cells are injected in the correct place?
How soon can I return to my regular activities?
Is cellular therapy approved by the FDA?
Cellular Therapy Research
Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis
Full Text, 2017 (Jun. 19); Bansal, et. al.
Dr. Bunyak notes this text from the conclusion, “SVF combined with PRP has a great potential as a therapeutic agent in regenerative medicine especially in orthopedic conditions. The high numbers of MSCs in SVF make it a suitable source for cellular medicine. Preliminary studies suggest that it is a safe and effective method for treating osteoarthritis. Both qualitative and quantitative measurements showed statistically significant improvements during the follow up period of 2 years.”
Mesenchymal Stem Cell-Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis
Full Text, 2017 (Dec. 21); Kay, et. al.
Dr. Bunyak notes, “MSC-conditioned media (containing exosomes and signalling molecules) reduces cartilage damage and suppresses inflammation in inflammatory arthritis.”
Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue
Full Text, 2017 (Dec. 6); Xu, et. al.
Dr. Bunyak notes this text from the conclusion, “The epigenetic memory obtained from either bone marrow or adipose tissue favored MSC (mesenchymal stem cells) differentiation along an osteoblastic or adipocytic lineage. The methylation status of the main transcription factors controlling MSC fate contributes to the differential differentiation capacities of different source-derived MSCs.”
Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon
Full Text, 2018 (Jan. 3); Kim, et. al.
Dr. Bunyak notes, “BMAC-PRP (bone marrow aspirate concentrate therapy combined with PRP) improved pain and shoulder function in patients with partial tear of the rotator cuff tendon.”
Concentrated Bone Marrow Aspirate for the Treatment of Chondral Injuries and Osteoarthritis of the Knee
(Chahla, Dean, et. al., Orthopaedic Journal of Sports Medicine, 1/2016)
From the abstract: “All 3 studies regarding osteoarthritis and all 8 studies regarding focal chondral defects reported good to excellent overall outcomes with the use of BMAC.”
Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies (Zuk, Zhu, et. al.)
Adipose-Derived Stem Cells for Regenerative Medicine (Gimble, Katz, et. al.)
“These 2 articles talk about the similarities between the stem cells we can get from bone marrow and from fat. Fat-derived stem cells can be grown and differentiated in the lab into several tissues, including bone, cartilage, muscle, and nerve. Additionally, the fat-derived stem cells are easier, safer, and more comfortable to remove (a small liposuction technique vs. a bone marrow aspiration). A small liposuction produces many more mesenchymal stem cells per collection than a bone marrow aspiration, allowing us to inject many more stem cells during a same-day procedure and eliminating the need for a multi-day culturing process.”-Dr. Bunyak
Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy (Kaneda, Nakagami, et. al.)
“Comment from Dr. Bunyak coming soon.”-Dr. Bunyak
Adipose Derived Stem Cells: New Kids on the Block (Meliga, Druckers, et. al.)
“Comment from Dr. Bunyak coming soon.”-Dr. Bunyak