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Recent Research – The Knee

Dr. Bunyak has read and analyzed the following recent research on the knee.

2018 Publications

The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis

(Rahimzadeh, et. al., 1/4/2018)

Dr. Bunyak notes, “This study finds that both PRP and prolotherapy significantly lower patients’ pain scores related to knee osteoarthrtis, with PRP proving more effective than prolotherapy.”

2017 Publications

Circulating levels of proinflammatory mediators as potential biomarkers of post-traumatic knee osteoarthritis development

(Panina, et. al., 10/20/2017)

Dr. Bunyak notes, “This study shows that patients experiencing knee arthritis following an injury have increased levels of biomarkers that may help estimate future degeneration and the possible usefulness of therapies such as A2M (alpha-2 macroglobulin).”

Benefits of different postoperative treatments in patients undergoing knee arthroscopic debridement

(Vasavilbaso, et. al., 9/25/2017)

Dr. Bunyak notes, “HA (hyaluronic acid injections) and PRP (platelet-rich plasma therapy) both help with post-arthroscopy pain and function for arthritis and meniscal tears. In this study, the HA offered more benefit than PRP, and this benefit lasted 18 months.”

Conservatively treated knee injury is associated with knee cartilage matrix degeneration measured with MRI-based T2 relaxation times: data from the osteoarthritis initiative

(Hoffman, et. al., 8/9/2017)

Dr. Bunyak notes, “Significant knee injuries, as defined by an injury that limits the ability to walk for at least 2 days, are associated with (permanent) cartilage matrix abnormalities as shown on MRI, even without obvious morphologic abnormalities.”

Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis

(Bansal, et. al., 6/19/2017)

Dr. Bunyak notes this text from the conclusion, “SVF combined with PRP has a great potential as a therapeutic agent in regenerative medicine especially in orthopedic conditions. The high numbers of MSCs in SVF make it a suitable source for cellular medicine. Preliminary studies suggest that it is a safe and effective method for treating osteoarthritis. Both qualitative and quantitative measurements showed statistically significant improvements during the follow up period of 2 years.”